Studies on Diuretics. Ii. the Relationship between Glomerular Filtration Rate, Proximal Tubular Absorption of Sodium and Diuretic Efficacy of Mercurials.
نویسندگان
چکیده
منابع مشابه
Mechanisms Contributing to Unresponsiveness to Mercurial
The ultimate failure of edematous cardiac patients to respond to mercurial diuretics is well established. Although the older literature ascribed this to renal tubular accommodation to mercury, some patients have received mercurials for many years without manifesting such acquired tubular resistance. More recently, because of the potentiation of mercurial diuresis in previously unresponsive pati...
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Experimental analysis of renal regulation of sodium and chloride excretion is complicated by the fact that the functional contributions of the proximal and the distal tubular segments to the urinary electrolyte pattern cannot be readily separated. If electrolyte transport in one of these tubular sites could be significantly depressed without affecting the other, it might be possible to clarify ...
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1. The renal efficacy of urodilatin in humans has only been partly investigated. It is unknown whether intravenously infused urodilatin has an effect on sodium reabsorption in both the proximal and distal part of the nephron. 2. Twelve healthy subjects participated in this double-blind, placebo-controlled study in a cross-over design. They received, in a randomized order, a short term (60 min) ...
متن کاملThe effects of infusion of water on renal hemodynamics and the tubular reabsorption of sodium.
Anesthetized dogs receiving an infusion of chlorothiazide and ethacrynic acid were given 600-ml infusions of distilled water or dilute dextrose solutions. The absolute rate of tubular sodium reabsorption was depressed, and the glomerular filtration rate was increased during the water loading, despite the associated decreases in plasma sodium concentration and decreases in the filtered load of s...
متن کاملResponse to mercurial diuretics during alkalosis: a comparison of acute metabolic and chronic hypokalemic alkalosis in the dog.
A relationship between the action of mercurial diuretics and acid-base metabolism has been established for many years. Diuresis may be augmented by the administration of acidifying salts such as ammonium chloride (1), and may be decreased or even totally inhibited by alkalinizing agents (2, 3). Although a variety of clinical and experimental studies suggest that the mercurials act by decreasing...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 29 3 شماره
صفحات -
تاریخ انتشار 1950